Wiley J, Balster R, Martin B
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0613, USA.
Eur J Pharmacol. 1995 Mar 24;276(1-2):49-54. doi: 10.1016/0014-2999(95)00010-i.
Anandamide (arachidonylethanolamide), a putative endogenous ligand for the cannabinoid receptor, produces a tetrad of behavioral effects in mice characteristic of psychoactive cannabinoids including catalepsy, antinociception, hypothermia, and hypomobility. The present study examined the discriminative stimulus effects of anandamide in rats trained to discriminate delta 9-tetrahydrocannabinol or the potent cannabinoid receptor ligand CP 55,940 [(-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)-phenyl]-trans-4-(3- hydroxypropyl)cyclohexanol)] from vehicle. Intraperitoneal injections of anandamide substituted for delta 9-tetrahydrocannabinol and for CP 55,940; however, unlike substitution dose-effect curves with the training drugs, anandamide substitution occurred at a single dose (30 or 45 mg/kg) and was accompanied by severe decreases in response rates. The results of the present study suggest that, although systemic anandamide administration may have cannabimimetic effects similar to those of delta 9-tetrahydrocannabinol and CP 55,940, some differences in the behavioral effects of anandamide and other psychoactive cannabinoids also are apparent.
花生四烯酸乙醇胺（N-花生四烯酸乙醇胺）是一种假定的大麻素受体内源性配体，它在小鼠身上产生了一系列行为效应，这些效应是具有精神活性的大麻素所特有的，包括僵住症、抗伤害感受、体温过低和活动减少。本研究考察了花生四烯酸乙醇胺对经训练以区分Δ9-四氢大麻酚或强效大麻素受体配体CP 55,940 [(-)-顺式-3-[2-羟基-4-(1,1-二甲基庚基)-苯基]-反式-4-(3-羟丙基)环己醇]与溶剂的大鼠的辨别刺激效应。腹腔注射花生四烯酸乙醇胺可替代Δ9-四氢大麻酚和CP 55,940；然而，与训练药物的替代剂量效应曲线不同，花生四烯酸乙醇胺的替代发生在单一剂量（30或45毫克/千克），并伴随着反应率的严重下降。本研究结果表明，虽然全身性给予花生四烯酸乙醇胺可能具有与Δ9-四氢大麻酚和CP 55,940类似的拟大麻效应，但花生四烯酸乙醇胺与其他精神活性大麻素在行为效应上也存在一些差异。
