Nash J Q, Chandrakumar M, Farrington C P, Williamson S, Miller E
Public Health Laboratory, William Harvey Hospital, Ashford, Kent.
Epidemiol Infect. 1995 Jun;114(3):475-80. doi: 10.1017/s0950268800052183.
To investigate the feasibility of using a record linkage method for identifying vaccine attributable adverse events, computerized hospital admissions and vaccination records from South East Kent district were linked and checked for accuracy. Records for 90% of children under 2 years of age admitted to hospital over a 2-year period were matched with vaccination records using a computer algorithm based on name, date of birth, sex, and post-code supplemented by visual inspection. Relative to this gold standard, matching on date of birth, sex and postcode alone had a sensitivity of 60% and an incorrect match rate of 0.2% after matches to more than one vaccine recipient were excluded. Manual checking of a sample of admissions showed that only 4% had been assigned incorrect International Classification of Disease (ICD) codes. Routine record linkage of ICD admission codes to vaccination records therefore yields data of good quality which may be used for surveillance purposes.
为研究使用记录链接方法识别疫苗所致不良事件的可行性，对来自肯特郡东南部地区的计算机化医院入院记录和疫苗接种记录进行了链接并检查其准确性。在两年期间，90%的2岁以下住院儿童的记录通过基于姓名、出生日期、性别和邮政编码的计算机算法，并辅以目视检查，与疫苗接种记录进行了匹配。相对于这个金标准，仅根据出生日期、性别和邮政编码进行匹配时，排除与多个疫苗接种者匹配的情况后，灵敏度为60%，错误匹配率为0.2%。对一部分入院记录样本进行人工检查发现，只有4%被分配了错误的国际疾病分类（ICD）代码。因此，将ICD入院代码与疫苗接种记录进行常规记录链接可产生高质量的数据，可用于监测目的。
