Mukhopadhyay M, Campos A R
Department of Biology, McMaster University, Hamilton, Ontario, Canada.
Dev Biol. 1995 Jun;169(2):629-43. doi: 10.1006/dbio.1995.1175.
The larval visual system in the fruitfly Drosophila melanogaster consists of two bilateral clusters of 12 photoreceptor cells. These neurons send their axons in a fascicle, the Bolwig's nerve, toward the target area in the ventral lateral region of the brain hemispheres. We describe the development of a serotonergic arborization originating in the central brain found in the larval optic center in association with the larval optic nerve. This arborization is formed by processes from larval neurons born during embryogenesis. However, these neuronal processes do not reach their final destination, the larval optic center, until late in larval development. Using mutations that disrupt the connectivity and/or development of the larval photoreceptor cells, as well as mosaic analysis, we demonstrate that the innervation of the larval optic center by this serotonergic arborization depends upon contact with the larval optic nerve.
果蝇黑腹果蝇的幼虫视觉系统由两簇各含12个光感受器细胞的双侧集群组成。这些神经元将它们的轴突以束状形式，即博尔维格神经，朝向脑半球腹外侧区域的目标区域发送。我们描述了一种起源于中枢脑的5-羟色胺能分支的发育情况，该分支在幼虫视觉中心与幼虫视神经相关联。这种分支由胚胎发育期间产生的幼虫神经元的突起形成。然而，这些神经元突起直到幼虫发育后期才到达它们的最终目的地，即幼虫视觉中心。利用破坏幼虫光感受器细胞的连接性和/或发育的突变，以及镶嵌分析，我们证明这种5-羟色胺能分支对幼虫视觉中心的神经支配依赖于与幼虫视神经的接触。
