Caballero A, Keightley P D, Hill W G
Institute of Cell, Animal and Population Biology, University of Edinburgh.
Genet Res. 1995 Apr;65(2):145-9. doi: 10.1017/s0016672300033152.
The variation from spontaneous mutations for 6-week body weight in the mouse was estimated by selection from a cross of two inbred sublines, C57BL/6 and C57BL/10, separated about 50 years previously from the same inbred line. Selection was practised high and low for 12 generations from the F2, followed by one generation of relaxation. The lines diverged by approximately 1.7 g or 0.7 sd. The additive genetic variance was estimated in the F2 by restricted maximum likelihood and from the selection response, and from this variance the mutational heritability hM2 was estimated using the number of generations since divergence. Estimates of hM2 range from 0.08 to 0.10% depending on the method of analysis. These estimates are similar to those found for other species, but lower than other estimates for the mouse. It is concluded that substantial natural and, perhaps, artificial selection operated during the maintenance of the sublines.
通过从两个大约在50年前从同一近交系中分离出来的近交亚系C57BL/6和C57BL/10的杂交后代中进行选择，估计了小鼠6周龄体重自发突变的变异情况。从F2代开始进行了12代的高低选择，随后进行了一代放松选择。品系间的差异约为1.7克或0.7个标准差。通过限制最大似然法在F2代中估计加性遗传方差，并根据选择反应进行估计，然后利用自分化以来的世代数从该方差中估计突变遗传力hM2。根据分析方法的不同，hM2的估计值在0.08%至0.10%之间。这些估计值与其他物种的估计值相似，但低于对小鼠的其他估计值。得出的结论是，在亚系的维持过程中存在大量的自然选择，或许还有人工选择。
