Jost W H
Neurologische Universitätsklinik Homburg/Saar.
Fortschr Neurol Psychiatr. 1995 May;63(5):194-205. doi: 10.1055/s-2007-996616.
Ever since the first description of Parkinson's disease, it has not only been associated with the classical triad of akinesia, rigor and tremor but also with autonomic regulation disorders. However, the studies published on this subject show differing and partly contradictory results. A large number of studies demonstrate a distinct autonomic disorder. On the other hand there are authors who question an affliction of the autonomic nervous system and others who attribute the autonomic disorder to Parkinson specific medication. To make matters worse, the various pathogeneses of Parkinson's syndrome within the patients collectives have not been sufficiently differentiated and nomenclature of the multisystem degeneration was handled in different ways. Taking our examinations of the various autonomic functions and the underlying literature into critical consideration, we come to the conclusion that regulation disorders of the cardiovascular system, gastrointestinal and urinary tract, as well as sweat and thermoregulation are often seen in the idiopathic Parkinson's disease. In our opinion the idiopathic Parkinson's syndrome must be attributed to the multisystem degenerations. Autonomic dysfunction occurs in different intensities in the disease.
自从首次描述帕金森病以来，它不仅与运动不能、僵硬和震颤这一经典三联征相关，还与自主神经调节障碍有关。然而，关于该主题发表的研究结果各异，部分相互矛盾。大量研究表明存在明显的自主神经障碍。另一方面，有作者质疑自主神经系统是否受累，还有些作者将自主神经障碍归因于帕金森病特异性药物。更糟糕的是，患者群体中帕金森综合征的各种发病机制尚未得到充分区分，多系统变性的命名方式也各不相同。综合考虑我们对各种自主神经功能的检查及相关文献，我们得出结论，特发性帕金森病常出现心血管系统、胃肠道和泌尿系统以及出汗和体温调节的调节障碍。我们认为特发性帕金森综合征应归因于多系统变性。自主神经功能障碍在该疾病中表现出不同程度。
