Martignoni E, Micieli G, Cavallini A, Pacchetti C, Magri M, Nappi G
J Neural Transm Suppl. 1986;22:149-61.
Clinical evidences and experimental data on various signs and symptoms of autonomic dysfunction in idiopathic parkinsonism are reported and their characteristics related to the effects of the drugs usually administered for the therapy of the extrapyramidal symptoms. The use of instrumental diagnostic criteria may sometimes help to detect alterations of autonomic functions (micturition disturbances, disorders of pupil reactivity, orthostatic and postprandial hypotension, temperature dysregulation), otherwise not easily identifiable. The existence of a large involvement of autonomic structures both at central and peripheral levels underlines the concept of Parkinson's disease being part of a wide spectrum of degenerative disorders where multiple nervous structures are at risk.
报告了特发性帕金森病自主神经功能障碍各种体征和症状的临床证据及实验数据，以及它们与通常用于治疗锥体外系症状的药物疗效相关的特征。使用仪器诊断标准有时有助于检测自主神经功能的改变（排尿障碍、瞳孔反应性障碍、体位性和餐后低血压、体温调节障碍），否则这些改变不易识别。自主神经结构在中枢和外周水平均有大量受累，这突出了帕金森病是广泛退行性疾病谱的一部分这一概念，在这些疾病中多个神经结构都有风险。
