Thapar A, McGuffin P
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, U.K.
J Child Psychol Psychiatry. 1995 Mar;36(3):439-47. doi: 10.1111/j.1469-7610.1995.tb01301.x.
Although childhood anxiety appears to aggregate in families, transmission could be explained by both genetic and shared environmental factors. Twin studies can be used to disentangle genetic and environmental effects. In this study, a systematically ascertained sample of twins was used to investigate whether anxiety symptoms are heritable. Parent-rated anxiety symptoms could best be explained by an additive genetic model with heritability estimated at 59%. However, when self ratings were analysed (in the adolescent subsample), familial transmission could be accounted for by shared environmental factors only.
尽管儿童焦虑症似乎在家族中具有聚集性，但遗传因素和共同的环境因素都可能导致这种遗传现象。双胞胎研究可用于区分遗传和环境影响。在本研究中，我们使用了一个经过系统确定的双胞胎样本，来调查焦虑症状是否具有遗传性。父母评定的焦虑症状最好用加性遗传模型来解释，遗传率估计为59%。然而，当分析自我评定结果时（在青少年子样本中），家族遗传现象只能由共同的环境因素来解释。
