Thapar A, Hervas A, McGuffin P
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK.
Behav Genet. 1995 Nov;25(6):537-44. doi: 10.1007/BF02327577.
Hyperactivity has consistently been shown to be familial. Until recently however, due to a lack of systematic twin evidence, it has remained uncertain to what extent familial transmission can be explained by genetic factors. We used a systematically ascertained population-based sample of twin pairs aged between 8 and 16 years old to explore the role of genetic influences on maternally rated hyperactivity scores. Hyperactivity scores were found to be substantially heritable. The data were best explained by a model which incorporated sibling competitive effects as well as additive genetic factors. These findings suggest not only that hyperactivity scores are influenced by genetic factors but that sibling interaction effects are also of importance.
多动一直被证明具有家族性。然而，直到最近，由于缺乏系统的双胞胎证据，家族遗传在多大程度上可由遗传因素来解释仍不明确。我们使用了一个基于系统确定的8至16岁双胞胎对的人群样本，以探讨遗传影响对母亲评定的多动分数的作用。结果发现多动分数具有高度遗传性。用一个纳入同胞竞争效应以及加性遗传因素的模型能最好地解释这些数据。这些发现不仅表明多动分数受遗传因素影响，而且同胞互动效应也很重要。
