Matoltsy A G
J Invest Dermatol. 1976 Jul;67(1):20-5. doi: 10.1111/1523-1747.ep12512473.
Early studies have already shown that the tonofibrils of malpighian cells consist of a --SH containing fibrous alpha-protein. It was assumed that the highly resistant protective substance, keratin, was formed by the conversion of --SH groups into --S--S--bonds in this protein. This chemical reaction was regarded as the most significant event of the keratinization process. Recent studies show that keratinization proceeds by a synthetic and a degradative stage and that ultimately a complex protective substance is formed. Horny cells become filled with --SH-containing filaments embedded in a --S--S---rich amorphous matrix. This complex is encased by a thickened membrane rendered insoluble by --S--S bonds and an unknown, highly resistant bond. In the stratum corneum, the intercellular space is occupied by bipolar lipids originating from the discharged lamellae of membrane-coating granules.
早期研究已经表明，马尔皮基细胞的张力原纤维由一种含巯基的纤维状α蛋白组成。据推测，这种蛋白质中巯基转化为二硫键会形成高抗性的保护物质角蛋白。该化学反应被认为是角质化过程中最重要的事件。最近的研究表明，角质化过程包括合成阶段和降解阶段，最终形成一种复杂的保护物质。角质形成细胞充满了嵌入富含二硫键的无定形基质中的含巯基细丝。这种复合物被一层由二硫键和一种未知的高抗性键使其不溶的增厚膜包裹。在角质层中，细胞间空间被源自膜包被颗粒排出片层的双极脂质占据。
