Dube B, Arora A, Singh V P, Kumar K, Sundar S
Department of Medicine, Banaras Hindu University, Varanasi, India.
J Trop Med Hyg. 1995 Jun;98(3):166-8.
Platelet function studies were conducted on 25 parasitologically positive cases of Indian kala-azar and 25 age and sex matched healthy controls. Ninety-two per cent of patients had thrombocytopenia of variable degree; in 44% of patients, platelets were less than 60,000 mm-3. The platelet adhesive index was less than 30% in 70% of patients with kala-azar (normal 31-60%). Platelet aggregation time with ADP and adrenaline was abnormally prolonged compared to the controls. Platelet factor III availability was poor in 40% of cases. There was a fair degree of correlation between platelet adhesiveness and platelet factor III availability in these patients: 50% of patients with poor platelet adhesiveness showed reduced platelet factor III availability.
对25例经寄生虫学检查确诊的印度黑热病患者及25例年龄和性别匹配的健康对照者进行了血小板功能研究。92%的患者有不同程度的血小板减少；44%的患者血小板计数低于60,000/mm³。70%的黑热病患者血小板黏附指数低于30%（正常为31 - 60%）。与对照组相比，患者对ADP和肾上腺素的血小板聚集时间异常延长。40%的病例血小板第III因子活性降低。这些患者的血小板黏附性与血小板第III因子活性之间存在一定程度的相关性：50%血小板黏附性差的患者血小板第III因子活性降低。
