Matsushime H
Department of Genetics Institute of Medical Science, University of Tokyo.
Rinsho Ketsueki. 1995 May;36(5):406-9.
Temporally orderly activation of the cyclin-dependent kinases (cdks) governs the progression and the transitions of the cell cycle in mammalian cells. Macrophages require a specific growth factor, M-CSF/CSF-1, for their proliferation throughout the G1 phase of the cell cycle. Once cells enter S phase, macrophages complete mitosis in the absence of M-CSF/CSF-1. During the G1 phase, cyclin D1 is induced by M-CSF/CSF-1 stimulation and forms enzymatically active complex with cdk 4. The enzymatic activity of the cyclin D1 and cdk 4 complex could be negatively regulated by recently reported inhibitory proteins to determine the timing for entry into S phase in macrophages.
细胞周期蛋白依赖性激酶（cdks）的时间顺序激活控制着哺乳动物细胞中细胞周期的进程和转换。巨噬细胞在整个细胞周期的G1期增殖需要特定的生长因子M-CSF/CSF-1。一旦细胞进入S期，巨噬细胞在没有M-CSF/CSF-1的情况下完成有丝分裂。在G1期，细胞周期蛋白D1由M-CSF/CSF-1刺激诱导，并与cdk 4形成酶活性复合物。细胞周期蛋白D1和cdk 4复合物的酶活性可能受到最近报道的抑制蛋白的负调控，以确定巨噬细胞进入S期的时间。
