巨噬细胞细胞周期。
Macrophage Cell Cycle.
机构信息
Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
Laboratoire Huckert's International, Wavre, Belgium.
出版信息
Results Probl Cell Differ. 2024;74:119-134. doi: 10.1007/978-3-031-65944-7_4.
Macrophages are dynamic and plastic immune cells essential for tissue homeostasis and pathogen defense. Their cell cycle regulation is highly influenced by intrinsic and extrinsic signals facilitating rapid responses to infections and tissue damage. Dysregulation of their cell cycle leads to diseases like cancer and HIV. This chapter highlights aspects of the macrophage cell cycle crucial for the development of targeted therapies.
巨噬细胞是具有动态和可塑性的免疫细胞，对于组织稳态和病原体防御至关重要。它们的细胞周期调控受到内在和外在信号的强烈影响，有助于对感染和组织损伤做出快速反应。它们的细胞周期失调会导致癌症和艾滋病等疾病。本章强调了巨噬细胞细胞周期对于靶向治疗发展至关重要的方面。
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