载脂蛋白E基因型、总胆固醇水平、年龄和性别在阿尔茨海默病预测中的相互作用：一项病例对照研究。
Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study.
作者信息
Jarvik G P, Wijsman E M, Kukull W A, Schellenberg G D, Yu C, Larson E B
机构信息
Department of Medicine, University of Washington Medical Center, Seattle, WA 98195, USA.
出版信息
Neurology. 1995 Jun;45(6):1092-6. doi: 10.1212/wnl.45.6.1092.
OBJECTIVE
The joint effects of total cholesterol (TC) levels and the APOE genotype in Alzheimer's disease (AD) were evaluated because of previous reports that the APOE locus epsilon 4 allele was associated with both late-onset AD and elevated TC.
DESIGN
Logistic regression was used to determine the effects of the APOE genotype, TC, age, and sex on prediction of AD in a community-based study of 206 cases and 276 controls.
RESULTS
The relationship of the APOE genotype and AD was dependent on TC, age, and sex. However, current TC level does not fully explain the epsilon 4-Alzheimer's disease association. Affected men with higher TC and age under 80 years had the highest epsilon 4 allele frequencies. The epsilon 4 frequency declined significantly with age.
SIGNIFICANCE
A pathologic role of higher TC or cholesterol-based differential survival of epsilon 4-carrying individuals may be involved in the relationship of the epsilon 4 allele with AD. The observed association of the APOE genotype and AD is expected to depend on the age, sex, and TC distributions of a given sample.
目的
由于先前有报道称载脂蛋白E（APOE）基因座ε4等位基因与晚发性阿尔茨海默病（AD）及总胆固醇（TC）升高均相关，因此评估了TC水平与APOE基因型在AD中的联合作用。
设计
在一项基于社区的研究中，对206例病例和276例对照使用逻辑回归来确定APOE基因型、TC、年龄和性别对AD预测的影响。
结果
APOE基因型与AD的关系取决于TC、年龄和性别。然而，当前的TC水平并不能完全解释ε4与阿尔茨海默病的关联。TC较高且年龄在80岁以下的患病男性中ε4等位基因频率最高。ε4频率随年龄显著下降。
意义
较高的TC或携带ε4个体基于胆固醇的差异生存的病理作用可能参与了ε4等位基因与AD的关系。观察到的APOE基因型与AD的关联预计取决于给定样本的年龄、性别和TC分布。
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