Rao H, Jean A, Kessler J P
Neurobiologie et Neurophysiologie fonctionnelles, URA CNRS 1832 Faculté Saint-Jérôme, Marseille, France.
Neurosci Lett. 1995 Mar 16;188(1):21-4. doi: 10.1016/0304-3940(95)11383-8.
Changes in [3H]glutamate (Glu) binding occurring in the lower medulla of the rat between birth (P0) and adulthood (P72) were investigated on cryostat sections using in vitro receptor autoradiography. Densitometric measurements were performed in both autonomic (nucleus tractus solitarii, dorsal motor nucleus of the vagus nerve, ventrolateral medulla) and non-autonomic (inferior olive, spinal trigeminal nucleus) medullary regions. In all these areas, binding densities peaked at P9 and then gradually declined. Values close to those measured in adult animals were reached by P23-P30. These data indicate that glutamatergic neurotransmission within the lower medulla undergoes developmental changes during the early postnatal period. They thereby suggest that the neural circuits essential in organizing autonomic functions are still immature at birth.
采用体外受体放射自显影技术，在冷冻切片上研究了出生时（P0）至成年期（P72）大鼠延髓下部[³H]谷氨酸（Glu）结合的变化。在自主神经（孤束核、迷走神经背运动核、延髓腹外侧）和非自主神经（下橄榄核、三叉神经脊束核）的延髓区域进行了光密度测量。在所有这些区域，结合密度在P9时达到峰值，然后逐渐下降。到P23 - P30时达到接近成年动物测量的值。这些数据表明，出生后早期延髓下部的谷氨酸能神经传递经历了发育变化。因此，它们表明在出生时，组织自主神经功能所必需的神经回路仍然不成熟。
