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因鼻腔使用倍他米松导致的医源性库欣综合征：一个不容忽视的问题！

Iatrogenic Cushing's syndrome due to nasal betamethasone: a problem not to be sniffed at!

作者信息

Nutting C M, Page S R

机构信息

Department of Medicine, University Hospital, Nottingham, UK.

出版信息

Postgrad Med J. 1995 Apr;71(834):231-2. doi: 10.1136/pgmj.71.834.231.

DOI:10.1136/pgmj.71.834.231
PMID:7784285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2398050/
Abstract

Nasal steroid drops for the treatment of allergic rhinitis can cause iatrogenic Cushing's syndrome and care should be taken with their use in clinical practice.

摘要

用于治疗变应性鼻炎的鼻用类固醇滴鼻剂可引起医源性库欣综合征，临床使用时应谨慎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f98/2398050/039a0bafea0a/postmedj00028-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f98/2398050/039a0bafea0a/postmedj00028-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f98/2398050/039a0bafea0a/postmedj00028-0041-a.jpg

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Iatrogenic Cushing's syndrome due to nasal betamethasone: a problem not to be sniffed at!因鼻腔使用倍他米松导致的医源性库欣综合征：一个不容忽视的问题！
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2
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本文引用的文献

1
On the various forms of corticosteroid withdrawal syndrome.论皮质类固醇戒断综合征的各种形式。
Am J Med. 1980 Feb;68(2):224-30. doi: 10.1016/0002-9343(80)90358-7.
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Adrenal function during the use of dexamethasone aerosols in the treatment of ragweed hay fever.
J Allergy. 1967 Jul;40(1):57-61. doi: 10.1016/0021-8707(67)90060-3.
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Cushing's syndrome due to the abuse of betamethasone nasal drops.
J Laryngol Otol. 1988 Mar;102(3):219-21. doi: 10.1017/s0022215100104566.
4
在 ACTH 依赖性库欣综合征的诊断中应用中心静脉取样和磁共振成像。
Neuroradiol J. 2023 Jun;36(3):341-345. doi: 10.1177/19714009221126016. Epub 2022 Sep 8.
4
Iatrogenic Cushing's syndrome as a consequence of nasal use of Betamethasone spray during pregnancy.孕期鼻腔使用倍他米松喷雾剂导致的医源性库欣综合征。
Acta Endocrinol (Buchar). 2020 Oct-Dec;16(4):511-517. doi: 10.4183/aeb.2020.511.
5
Avascular Necrosis of Both Hips From Iatrogenic Cushing 's Syndrome due to Coadministration of Fluticasone and Ritonavir in an HIV-Infected Patient.一名HIV感染患者因同时使用氟替卡松和利托那韦导致医源性库欣综合征并发双侧髋关节缺血性坏死
Cureus. 2020 Aug 10;12(8):e9644. doi: 10.7759/cureus.9644.
6
Iatrogenic Cushing's Syndrome Following Intra-Articular Triamcinolone Injection in an HIV-Infected Patient on Cobicistat Presenting as a Pulmonary Embolism: Case Report and Literature Review.在接受考比司他治疗的HIV感染患者中，关节腔内注射曲安奈德后发生医源性库欣综合征并表现为肺栓塞：病例报告及文献综述
Int Med Case Rep J. 2020 Jun 9;13:229-235. doi: 10.2147/IMCRJ.S254461. eCollection 2020.
7
Iatrogenic Cushing's syndrome in children following nasal steroid.儿童鼻用类固醇药物治疗后发生的医源性库欣综合征
Pan Afr Med J. 2014 Mar 28;17:237. doi: 10.11604/pamj.2014.17.237.3332. eCollection 2014.
8
Too little or too much corticosteroid? Coexisting adrenal insufficiency and Cushing's syndrome from chronic, intermittent use of intranasal betamethasone.皮质类固醇过少还是过多？长期间歇性使用鼻内倍他米松导致并存肾上腺功能不全和库欣综合征。
Endocrinol Diabetes Metab Case Rep. 2013;2013:130036. doi: 10.1530/EDM-13-0036. Epub 2013 Oct 4.
9
Safety and tolerability profiles of intranasal antihistamines and intranasal corticosteroids in the treatment of allergic rhinitis.鼻内用抗组胺药和鼻内用皮质类固醇治疗变应性鼻炎的安全性和耐受性概况。
Drug Saf. 2003;26(12):863-93. doi: 10.2165/00002018-200326120-00003.
10
Severe adrenal suppression by steroid nasal drops.类固醇滴鼻剂导致严重肾上腺抑制。
J R Soc Med. 2001 Jul;94(7):350-1. doi: 10.1177/014107680109400711.
Diagnosis of adrenal insufficiency.肾上腺功能不全的诊断。
BMJ. 1989 Feb 4;298(6669):271-2. doi: 10.1136/bmj.298.6669.271.
5
Psychiatric phenomenology in Cushing's disease.库欣病中的精神现象学。
Pharmacopsychiatry. 1992 Jul;25(4):192-8. doi: 10.1055/s-2007-1014405.
6
Adrenal suppression with intranasal betamethasone drops.
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7
Metabolism of beclomethasone dipropionate by animals and man.
Postgrad Med J. 1975;51 Suppl 4:11-20.
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Intranasal beclomethasone dipropionate aerosol in allergic nasal diseases.
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