[III型肠化生、年龄与胃癌的关系。560例活检]

[Relationship between type III intestinal metaplasia, age and gastric cancer. 560 biopsies].

作者信息

Rabouille Y, Elie H, Challes C

机构信息

Service d'Anatomie et de Cytologie pathologiques, Centre Hospitalier Louis Pasteur, Cherbourg.

出版信息

Presse Med. 1995;24(15):722-4.

PMID:7784405

Abstract

OBJECTIVE

A significant association between type III intestinal metaplasia and gastric adenocarcinoma has been demonstrated in gastrectomy and biopsy series. We investigated the effect of age in a large series of gastric biopsies in order to determine whether this association is age dependent or independent.

METHODS

Histochemistry examinations were performed in 560 gastric biopsies showing intestinal metaplasia. The percentage of type III versus type I/II metaplasia in patients with malignant (n = 41) or benign disease (n = 519) was compared between patients aged 50 to 69 years and patients aged 70 to 89 years.

RESULTS

The prevalence of type III metaplasia increased with age both in malignant (30 vs 61% in the 50-69 and 70-89 year age groups respectively) and benign disease (9 vs 17% respectively). In patients with cancer, type III metaplasia was found more often than type I/II metaplasia (n = 22 vs 19). In the 70-89 year age group, there was a significant difference (p < 0.001) in the percentage of type III metaplasia in patients with cancer (61%) and those with benign disease (17%).

CONCLUSION

These findings demonstrate that there is a specific age-independent relationship between intestinal metaplasia and gastric cancer.

摘要

目的

在胃切除术和活检系列研究中已证实III型肠化生与胃腺癌之间存在显著关联。我们在大量胃活检病例中研究了年龄的影响，以确定这种关联是否依赖于年龄。

方法

对560例显示肠化生的胃活检标本进行组织化学检查。比较了年龄在50至69岁和70至89岁的恶性疾病患者（n = 41）和良性疾病患者（n = 519）中III型化生与I/II型化生的百分比。

结果

III型化生的患病率在恶性疾病（50至69岁年龄组为30%，70至89岁年龄组为61%）和良性疾病（分别为9%和17%）中均随年龄增加。在癌症患者中，III型化生比I/II型化生更常见（n = 22对19）。在70至89岁年龄组中，癌症患者（61%）和良性疾病患者（17%）的III型化生百分比存在显著差异（p < 0.001）。