心肌病仓鼠（UM-X7.1）衰竭心脏中脂质代谢的改变。

Altered lipid metabolism in the failing heart of cardiomyopathic hamsters (UM-X7.1).

作者信息

Vecchini A, Binaglia L, Di Nardo P, Minieri M, Panagia V, Dhalla N S

机构信息

Institute of Biochemistry and Medical Chemistry, University of Perugia, Italy.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 1995 Feb-Mar;52(2-3):199-203. doi: 10.1016/0952-3278(95)90023-3.

DOI:10.1016/0952-3278(95)90023-3

PMID:7784458

Abstract

The lipid composition of different anatomic regions of 150 day-old UM-X7.1 cardiomyopathic hamster and age-matched controls (Syrian golden hamsters) was examined. Cardiomyopathic hamsters exhibit a phospholipid to protein ratio higher than healthy animals in atria, whereas the contrary is true in the other anatomic regions examined. In all tissues the cholesterol to phospholipid ratio is higher in cardiomyopathic hamster than in controls. Healthy and UM-X7.1 hamsters differ substantially as far as the percent distribution of fatty acids in total lipids is concerned, the lipids from cardiomyopathic animals accumulating fatty acids of the omega-6 series and being relatively poor in monoenoic fatty acids. The different fatty acid composition of heart lipids appears to be a consequence of a generalized disturbance of the lipid metabolism in cardiomyopathic hamsters during congestive heart failure.

摘要

对150日龄的UM - X7.1心肌病仓鼠以及年龄匹配的对照动物（叙利亚金黄仓鼠）不同解剖区域的脂质组成进行了检测。心肌病仓鼠心房中的磷脂与蛋白质之比高于健康动物，而在其他检测的解剖区域情况则相反。在所有组织中，心肌病仓鼠的胆固醇与磷脂之比高于对照动物。就总脂质中脂肪酸的百分比分布而言，健康仓鼠和UM - X7.1仓鼠有很大差异，心肌病动物的脂质积累ω-6系列脂肪酸，单烯脂肪酸相对较少。心脏脂质不同的脂肪酸组成似乎是心肌病仓鼠在充血性心力衰竭期间脂质代谢普遍紊乱的结果。