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气管内滴注后对金属过敏反应发展的延迟。

Delay in the development of the allergic response to metals following intratracheal instillation.

作者信息

Parker D, Turk J L

出版信息

Int Arch Allergy Appl Immunol. 1978;57(4):289-93. doi: 10.1159/000232117.

DOI:10.1159/000232117
PMID:77847
Abstract

Intracheal intubation with the soluble metal salts potassium dichromate (K2Cr2O7) and nickel sulphate (NiSO4) causes a delay of up to 8 weeks in the development of delayed hypersensitivity to the specific agent. It is suggested that absorption of sensitizers by the respiratory route may, under certain circumstances, induce a state of specific immunological unresponsiveness, rather than necessarily lead to the development of a state of allergic sensitivity.

摘要

使用可溶性金属盐重铬酸钾（K2Cr2O7）和硫酸镍（NiSO4）进行气管插管会导致对特定药剂的迟发型超敏反应的发展延迟长达8周。有人提出，在某些情况下，致敏剂通过呼吸道吸收可能会诱发一种特异性免疫无反应状态，而不一定导致过敏敏感状态的发展。

相似文献

1
Delay in the development of the allergic response to metals following intratracheal instillation.气管内滴注后对金属过敏反应发展的延迟。
Int Arch Allergy Appl Immunol. 1978;57(4):289-93. doi: 10.1159/000232117.
2
Delayed-type hypersensitivity reaction in the lungs of guinea pigs due to potassium dichromate.重铬酸钾导致豚鼠肺部迟发型超敏反应。
J Allergy Clin Immunol. 1975 Dec;56(6):464-72. doi: 10.1016/0091-6749(75)90064-0.
3
Intrapulmonary pretreatment by metal-fume components causing inhibition of delayed hypersensitivity.金属烟雾成分引起的肺内预处理对迟发型超敏反应的抑制作用。
Arch Toxicol Suppl. 1987;11:223-6. doi: 10.1007/978-3-642-72558-6_37.
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Flare-up reactions and desensitization from oral dosing in chromate-sensitive guinea pigs.铬酸盐敏感豚鼠口服给药后的 flare-up 反应和脱敏作用
Contact Dermatitis. 1984 May;10(5):277-9. doi: 10.1111/j.1600-0536.1984.tb00146.x.
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Comparison of DNFB and K2Cr2O7 'flare-up' reactions in the guinea pig.豚鼠中DNFB与重铬酸钾“激发”反应的比较。
Int Arch Allergy Appl Immunol. 1984;73(2):123-8. doi: 10.1159/000233451.
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Sensitization with Cr, Ni and Zr salts and allergic type granuloma formation in the guinea pig.豚鼠中铬、镍和锆盐致敏及过敏性肉芽肿形成
J Invest Dermatol. 1977 Jun;68(6):341-5. doi: 10.1111/1523-1747.ep12496465.
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Evaluation of skin sensitization potential of nickel, chromium, titanium and zirconium salts using guinea-pigs and mice.
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The induction of an allergic gastritis of delayed-type in guinea pigs sensitized to potassium bichromate--further studies on the gastritis related to contact allergy.对重铬酸钾致敏的豚鼠迟发型过敏性胃炎的诱导——与接触性过敏相关胃炎的进一步研究
Osaka City Med J. 1977;23(1):109-15.
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Elimination of nickel, cobalt, and chromium following repeated injections of high dose metal salts.
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Effect of combined administration of DL-penicillamine and potassium dichromate on lethality, distribution and excretion of chromium in mice.
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