Miyamoto T, Ichikawa K, Kabe J, Horiuchi Y
J Allergy Clin Immunol. 1975 Dec;56(6):464-72. doi: 10.1016/0091-6749(75)90064-0.
Potassium dichromate was inhaled by guinea pigs previously immunized by potassium dichromate until strong positive patch tests were obtained. No obvious respiratory changes were noted during and after inhalation. Histologically, however, mononuclear cells infiltrated the interstitial spaces in large areas of the lung, producing considerable thickening of the alveolar spaces in 24 to 48 hr after inhalation. Polymorphonuclear cells were predominant initially. These changes were similar to the delayed-type hypersensitivity reaction in the lung elicited by the inhalation of purified protein derivative (PPD) in the guinea pigs immunized by an injection of dry-killed tubercle bacilli. A less marked reaction was observed in guinea pigs passively sensitized with peritoneal exudate cells and lymph node cells. Consequently, the pulmonary changes were thought to be elicited by delayed-type hypersensitivity reaction due to a simple chemical. The clinical implications of delayed-type hypersensitivity reaction in the lung due to simple chemicals are discussed.
用重铬酸钾对豚鼠进行免疫，直至获得强阳性斑贴试验结果，然后让这些豚鼠吸入重铬酸钾。在吸入过程中及吸入后均未观察到明显的呼吸变化。然而，组织学检查显示，吸入后24至48小时，单核细胞浸润了肺的大片间质空间，导致肺泡间隙明显增厚。最初多形核细胞占主导。这些变化类似于在注射灭活结核杆菌免疫的豚鼠中吸入纯化蛋白衍生物（PPD）后在肺部引发的迟发型超敏反应。在用腹膜渗出细胞和淋巴结细胞被动致敏的豚鼠中观察到的反应不太明显。因此，肺部变化被认为是由一种简单化学物质引起的迟发型超敏反应所致。本文讨论了由简单化学物质引起的肺部迟发型超敏反应的临床意义。
