Shvemberger I N, Ginkul L B, Ermilov A N
Vopr Onkol. 1994;40(4-6):198-202.
Transgenic mice carrying two delta-gag-myc genetic constructions were produced and kept under observation during their whole life. Nineteen out of 119 transgenic mice developed such hemopoietic diseases as lymphoid tissue hyperplasia, lymphoma, lymphosarcoma and myeloma. Lymphoid tissue hyperplasia and lymphoma generally involved multiple hyperplastic and neoplastic pathologies which were regarded, on the whole, as "malignant disease". In all cases, lymphosarcoma and myeloma were the only deadly pathologies. Lymphomas and myelomas were detected after 3-9 months, lymphosarcomas--18-29 months while lymphoid tissue hyperplasia occurred virtually throughout the entire life span--3-31 months. The study has shown that transgenic mice carrying delta-gag-myc gene in their genome can be used in the designing of special models for investigations of certain patterns of leukemia.
携带两种δ - gag - myc基因构建体的转基因小鼠被培育出来，并在其整个生命周期内进行观察。119只转基因小鼠中有19只患上了诸如淋巴组织增生、淋巴瘤、淋巴肉瘤和骨髓瘤等造血系统疾病。淋巴组织增生和淋巴瘤通常涉及多种增生性和肿瘤性病变，总体上被视为“恶性疾病”。在所有病例中，淋巴肉瘤和骨髓瘤是唯一致命的病变。淋巴瘤和骨髓瘤在3 - 9个月后被检测到，淋巴肉瘤在18 - 29个月后出现，而淋巴组织增生几乎在整个生命周期（3 - 31个月）都有发生。该研究表明，基因组中携带δ - gag - myc基因的转基因小鼠可用于设计特定模型，以研究某些白血病模式。
