Oyen N, Skjaerven R, Little R E, Wilcox A J
Medical Birth Registry of Norway, University of Bergen.
Am J Epidemiol. 1995 Jul 1;142(1):84-90. doi: 10.1093/oxfordjournals.aje.a117549.
To evaluate the intrauterine growth potential of infants that die from sudden infant death syndrome (SIDS), the authors compared SIDS infants with their surviving siblings. The SIDS sibships themselves were also compared with sibships where all infants survived. Data from the population-based Medical Birth Registry of Norway, with 1.3 million births during 1967-1988, were used. From the birth cohorts, 1,984 SIDS cases were identified. All births were linked into sibships. The mean birth weight and gestational age were calculated across sibships of different sizes for first to fourth birth order. In a further analysis, birth weights were standardized to adjust for gestational age. Mothers of SIDS infants give birth to smaller babies in general. SIDS infants weighed, on average, 85 g less at birth than their siblings and 164 g less compared with babies in nonaffected sibships. When birth weights were standardized for gestational age, most of the weight difference between SIDS infants and siblings was due to a shorter gestational age of SIDS infants, while the difference between surviving siblings of SIDS infants and births from nonaffected sibships remained. All births in sibships with a SIDS infant were intrauterine growth retarded. This may reflect factors that contribute to SIDS risk (such as maternal smoking). The factors that contribute to shorter gestational age and further slowing of growth in the SIDS infants may specifically influence the SIDS infant and not its siblings.
为评估死于婴儿猝死综合征（SIDS）的婴儿的宫内生长潜力，作者将SIDS婴儿与其存活的兄弟姐妹进行了比较。SIDS婴儿同胞组之间也与所有婴儿均存活的同胞组进行了比较。使用了挪威基于人群的医学出生登记处1967年至1988年期间130万例出生的数据。从出生队列中，识别出1984例SIDS病例。所有出生记录都被关联到同胞组中。计算了不同规模同胞组中第一至第四出生顺序的平均出生体重和胎龄。在进一步分析中，对出生体重进行标准化以校正胎龄。一般来说，SIDS婴儿的母亲生下的婴儿较小。SIDS婴儿出生时平均比其兄弟姐妹轻85克，与未受影响同胞组中的婴儿相比轻164克。当对出生体重进行胎龄标准化时，SIDS婴儿与其兄弟姐妹之间的大部分体重差异是由于SIDS婴儿的胎龄较短，而SIDS婴儿的存活兄弟姐妹与未受影响同胞组出生的婴儿之间的差异仍然存在。有SIDS婴儿的同胞组中的所有出生均存在宫内生长迟缓。这可能反映了导致SIDS风险的因素（如母亲吸烟）。导致SIDS婴儿胎龄较短和生长进一步减缓的因素可能特别影响SIDS婴儿而非其兄弟姐妹。
