Rankin S J, Walman B E, Buckley A R, Drance S M
Department of Ophthalmology, University of British Columbia, Vancouver, Canada.
Am J Ophthalmol. 1995 Jun;119(6):685-93. doi: 10.1016/s0002-9394(14)72771-0.
We used color Doppler imaging to study blood flow velocity in the central retinal artery and the short posterior ciliary arteries in patients with glaucoma.
Fifty-two patients with chronic open-angle glaucoma, 24 patients with normal-tension glaucoma, and 28 normal subjects were studied. The mean of the peak systolic velocity, the end diastolic velocity, and the resistive index were compared in the three groups.
Compared with the normal subjects, the patients with chronic open-angle glaucoma showed a statistically significant (P < .05) decrease in the mean end diastolic velocity and an increase in the mean resistive index in all vessels studied. The patients with normal-tension glaucoma showed similar changes, achieving significance most prominently in the central retinal arteries, compared with normal subjects (P < .05). There were no statistically significant differences between the patients with chronic open-angle glaucoma and those with normal-tension glaucoma.
Open-angle glaucoma appears to be associated with a decreased mean flow velocity and an increased mean resistive index in the ocular vasculature. These changes are in keeping with possibly compromised circulation in this region.
我们运用彩色多普勒成像技术研究青光眼患者视网膜中央动脉和睫状后短动脉的血流速度。
对52例慢性开角型青光眼患者、24例正常眼压性青光眼患者和28名正常受试者进行研究。比较三组受试者的收缩期峰值速度、舒张末期速度及阻力指数的平均值。
与正常受试者相比，慢性开角型青光眼患者所有研究血管的舒张末期平均速度显著降低（P <.05），阻力指数平均值升高。正常眼压性青光眼患者也有类似变化，与正常受试者相比，在视网膜中央动脉中最为显著（P <.05）。慢性开角型青光眼患者与正常眼压性青光眼患者之间无统计学显著差异。
开角型青光眼似乎与眼内血管系统平均血流速度降低和平均阻力指数升高有关。这些变化与该区域可能存在的血液循环受损情况相符。
