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利用多模态自适应光学成像测量人眼视网膜血流精度

Measurement of retinal blood flow precision in the human eye with multimodal adaptive optics imaging.

作者信息

Raghavendra Achyut J, Damani Aashka, Oechsli Saige, Magder Laurence S, Liu Zhuolin, Hammer Daniel X, Saeedi Osamah J

机构信息

Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

Center for Devices and Radiological Health (CDRH), U. S. Food and Drug Administration (FDA), Silver Spring, Maryland 20993, USA.

出版信息

Biomed Opt Express. 2024 Jul 11;15(8):4625-4641. doi: 10.1364/BOE.524944. eCollection 2024 Aug 1.

DOI:10.1364/BOE.524944
PMID:39346998
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11427214/
Abstract

Impaired retinal blood flow (RBF) autoregulation plays a key role in the development and progression of several ocular diseases, including glaucoma and diabetic retinopathy. Clinically, reproducible RBF quantitation could significantly improve early diagnosis and disease management. Several non-invasive techniques have been developed but are limited for retinal microvasculature flow measurements due to their low signal-to-noise ratio and poor lateral resolution. In this study, we demonstrate reproducible vessel caliber and retinal blood flow velocity measurements in healthy human volunteers using a high-resolution (spatial and temporal) multimodal adaptive optics system with scanning laser ophthalmoscopy and optical coherence tomography.

摘要

视网膜血流（RBF）自动调节受损在包括青光眼和糖尿病视网膜病变在内的几种眼部疾病的发生和发展中起关键作用。临床上，可重复的RBF定量可显著改善早期诊断和疾病管理。已经开发了几种非侵入性技术，但由于其低信噪比和较差的横向分辨率，在视网膜微血管血流测量方面受到限制。在本研究中，我们使用具有扫描激光检眼镜和光学相干断层扫描的高分辨率（空间和时间）多模态自适应光学系统，在健康人类志愿者中展示了可重复的血管管径和视网膜血流速度测量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11427214/4e50fb72cbea/boe-15-8-4625-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11427214/3655f1bbfc17/boe-15-8-4625-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11427214/18e58b4f01e2/boe-15-8-4625-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11427214/5190c74abc09/boe-15-8-4625-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11427214/a670f591fae5/boe-15-8-4625-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11427214/7971be737c39/boe-15-8-4625-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11427214/4e50fb72cbea/boe-15-8-4625-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11427214/3655f1bbfc17/boe-15-8-4625-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11427214/18e58b4f01e2/boe-15-8-4625-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11427214/5190c74abc09/boe-15-8-4625-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11427214/a670f591fae5/boe-15-8-4625-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11427214/7971be737c39/boe-15-8-4625-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bce/11427214/4e50fb72cbea/boe-15-8-4625-g006.jpg

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本文引用的文献

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High-speed, phase contrast retinal and blood flow imaging using an adaptive optics partially confocal multi-line ophthalmoscope.使用自适应光学部分共焦多线检眼镜进行高速、相衬视网膜和血流成像。
Biomed Opt Express. 2024 Feb 22;15(3):1815-1830. doi: 10.1364/BOE.507449. eCollection 2024 Mar 1.
2
Is Primary Open-Angle Glaucoma a Vascular Disease? Assessment of the Relationship between Retinal Arteriolar Morphology and Glaucoma Severity Using Adaptive Optics.原发性开角型青光眼是一种血管疾病吗？利用自适应光学评估视网膜小动脉形态与青光眼严重程度之间的关系。
J Clin Med. 2024 Jan 15;13(2):478. doi: 10.3390/jcm13020478.
3
Absolute retinal blood flow in healthy eyes and in eyes with retinal vein occlusion.
健康眼和视网膜静脉阻塞眼中的绝对视网膜血流。
Microvasc Res. 2024 Mar;152:104648. doi: 10.1016/j.mvr.2023.104648. Epub 2023 Dec 18.
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Analysis of retinal arteriolar and venular parameters in primary open angle glaucoma.原发性开角型青光眼视网膜小动脉和小静脉参数分析
Int J Ophthalmol. 2023 May 18;16(5):671-679. doi: 10.18240/ijo.2023.05.01. eCollection 2023.
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Introduction to the Feature Issue on Adaptive Optics for Biomedical Applications.生物医学应用中的自适应光学专题介绍。
Biomed Opt Express. 2023 Mar 30;14(4):1772-1776. doi: 10.1364/BOE.488044. eCollection 2023 Apr 1.
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High-speed measurement of retinal arterial blood flow in the living human eye with adaptive optics ophthalmoscopy.自适应光学眼底镜高速测量活体人眼视网膜动脉血流。
Opt Lett. 2023 Apr 15;48(8):1994-1997. doi: 10.1364/OL.480896.
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Evolution of adaptive optics retinal imaging [Invited].自适应光学视网膜成像的发展[特邀报告]
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Ultrahigh-speed multimodal adaptive optics system for microscopic structural and functional imaging of the human retina.用于人类视网膜微观结构和功能成像的超高速多模态自适应光学系统。
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