MacNeil R L, Berry J, D'Errico J, Strayhorn C, Somerman M J
Department of Periodontics/Prevention and Geriatrics, School of Dentistry, University of Michigan, Ann Arbor 48109-1078, USA.
Ann N Y Acad Sci. 1995 Apr 21;760:166-76. doi: 10.1111/j.1749-6632.1995.tb44628.x.
To summarize results from various studies focusing on determining the expression/localization of BSP and OPN during tooth root development, there is general agreement that OPN is expressed/localized to the root surface during cementogenesis and is also seen throughout the PDL region. The expression/localization of OPN to odontoblasts and its role in dentinogenesis is less apparent. Recent studies directed at establishing odontoblast cell lines should help to resolve this conflict. Studies on BSP expression during tooth root formation indicate a very precise expression and localization of this molecule during cementogenesis indicating that this molecule may play an important role in the formation of this mineralized tissue. However, as with OPN, the expression of BSP and its role in dentin formation is not clearly defined.
为总结各项聚焦于确定牙骨质生成过程中骨涎蛋白（BSP）和骨桥蛋白（OPN）表达及定位的研究结果，普遍认为在牙骨质形成过程中OPN表达于/定位于牙根表面，并且在整个牙周韧带区域也可见到。OPN在成牙本质细胞中的表达/定位及其在牙本质形成中的作用则不太明显。针对建立成牙本质细胞系的近期研究应有助于解决这一矛盾。关于牙根形成过程中BSP表达的研究表明，该分子在牙骨质形成过程中有非常精确的表达和定位，这表明该分子可能在这种矿化组织的形成中发挥重要作用。然而，与OPN一样，BSP的表达及其在牙本质形成中的作用尚未明确界定。
