2'-氟-5-甲基-β-L-阿拉伯呋喃糖基尿嘧啶作为一种新型抗乙型肝炎病毒和爱泼斯坦-巴尔病毒的抗病毒药物的用途。
Use of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus.
作者信息
Chu C K, Ma T, Shanmuganathan K, Wang C, Xiang Y, Pai S B, Yao G Q, Sommadossi J P, Cheng Y C
机构信息
Department of Medicinal Chemistry, College of Pharmacy, University of Georgia, Athens 30602, USA.
出版信息
Antimicrob Agents Chemother. 1995 Apr;39(4):979-81. doi: 10.1128/AAC.39.4.979.
Abstract
A novel anti-hepatitis B virus (anti-HBV) agent, 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil (L-FMAU), was synthesized and found to be a potent anti-HBV and anti-Epstein-Barr virus agent. Its in vitro potency was evaluated in 2.2.15 and H1 cells for anti-HBV and anti-Epstein-Barr virus activities, respectively. In vitro cytotoxicity in MT2, CEM, 2.2.15, and H1 cells was also assessed, and the results indicated high antiviral selectivities of L-FMAU in these cells.
摘要
一种新型抗乙型肝炎病毒（抗-HBV）药物2'-氟-5-甲基-β-L-阿拉伯呋喃糖基尿嘧啶（L-FMAU）被合成出来，并且发现它是一种有效的抗HBV和抗爱泼斯坦-巴尔病毒药物。分别在2.2.15细胞和H1细胞中评估了其体外抗HBV和抗爱泼斯坦-巴尔病毒活性的效力。还评估了L-FMAU在MT2、CEM、2.2.15和H1细胞中的体外细胞毒性，结果表明L-FMAU在这些细胞中具有高抗病毒选择性。
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