Moore R Y, Halaris A E, Jones B E
J Comp Neurol. 1978 Aug 1;180(3):417-38. doi: 10.1002/cne.901800302.
The ascending projections of serotonin neurons of the midbrain raphe were analyzed in the rat using the autoradiographic tracing method. Axons of raphe serotonin neurons ascend in the ventral tegmental area and enter the medial forebrain bundle. A number of fibers leave the major group to ascend along the fasciculus retroflexus. Some fibers enter the habenula but the majority turn rostrally in the internal medullary lamina of the thalamus to innervate dorsal thalamus. Two additional large projections leave the medial forebrain bundle in the hypothalamus; the ansa peduncularis-ventral amygdaloid bundle system turns laterally through the internal capsule into the striatal complex, amygdala and the external capsule to reach lateral and posterior cortex, and another system of fibers turns medially to innervate medial hypothalamus and median eminence and form a contrelateral projection via the supraoptic commissures. Rostrally the major group in the medial forebrain bundle divides into several components: fibers entering the stria medullaris to terminate in thalamus; fibers entering the stria terminalis to terminate in the amygdala; fibers traversing the fornix to the hippocampus; fibers running through septum to enter the cingulum and terminate in dorsal and medial cortex and in hippocampus; fibers entering the external capsule to innervate rostral and lateral cortex; and fibers continuing forward in the medial olfactory stria to terminate in the anterior olfactory nucleus and olfactory bulb.
采用放射自显影示踪法对大鼠中脑缝际5-羟色胺能神经元的上行投射进行了分析。缝际5-羟色胺能神经元的轴突在腹侧被盖区上行并进入内侧前脑束。许多纤维离开主要束沿缰核脚间束上行。一些纤维进入缰核，但大多数纤维在丘脑内侧髓板内转向嘴侧，支配背侧丘脑。另外有两个大的投射离开下丘脑的内侧前脑束；脚间袢-腹侧杏仁核束系统经内囊转向外侧，进入纹状体复合体、杏仁核和外囊，到达外侧和后皮质，另一纤维系统转向内侧，支配内侧下丘脑和正中隆起，并经视上连合形成对侧投射。在嘴侧，内侧前脑束中的主要束分为几个分支：进入髓纹并终止于丘脑的纤维；进入终纹并终止于杏仁核的纤维；穿过穹窿至海马的纤维；穿过隔区进入扣带并终止于背侧和内侧皮质以及海马的纤维；进入外囊支配嘴侧和外侧皮质的纤维；以及在内侧嗅纹中向前延续并终止于前嗅核和嗅球的纤维。
