Conrad L C, Pfaff D W
J Comp Neurol. 1976 Sep 15;169(2):185-219. doi: 10.1002/cne.901690205.
Efferent projections from the medial and periventricular preoptic area, bed nucleus of the stria terminalis and nuclei of the diagonal band were traced using tritiated amino acid autoradiography in albino rats. Medial and periventricular preoptic area efferents were not restricted to short-axon projections. Ascending projections from the medial preoptic area (mPOA) were traced through the diagonal band into the septum. Descending mPOA axons coursed in the medial parts of the medial forebrain bundle. Projections to most hypothalamic nuclei, including the arcuate nucleus and median eminence, were observed. In the midbrain, mPOA efferents were distributed in the central grey, raphe nuclei, ventral tegmental area and reticular formation. Projections from the mPOA were also observed to the amygdala through the stria terminalis, to the lateral habenula through the stria medullaris, and to the periventricular thalamus. Axons of the most medial and periventricular preoptic area (pvPOA) neurons had a distribution similar to more lateral mPOA neurons but their longest-axoned projections were weaker. The pvPOA did not send axons through the stria medullaris but did project more heavily than the more lateral mPOA to the arcuate nucleus and median eminence. Projections from the bed nucleus of the stria terminalis (nST) were in most respects similar to those from the medial preoptic area, with the major addition of a projection to the accessory olfactory bulb. The nuclei of the diagonal band of Broca (nDBB) gave a different pattern of projections than mPOA or nST, projecting, for instance, to the medial septum and hippocampus. Descending nDBB efferents ran in the ventral portion of the medial forebrain bundle. Among hypothalamic cell groups, only the medial mammillary nuclei received nDBB projections. nDBB efferents also distributed in the medial and lateral habenular nuclei and the mediodorsal thalamic nucleus.
运用氚标记氨基酸放射自显影技术，在白化大鼠中追踪了来自内侧和室周视前区、终纹床核以及斜角带核的传出投射。内侧和室周视前区的传出纤维并不局限于短轴突投射。内侧视前区（mPOA）的上行投射通过斜角带追踪至隔区。内侧视前区的下行轴突走行于内侧前脑束的内侧部分。观察到其投射至大多数下丘脑核团，包括弓状核和正中隆起。在中脑，内侧视前区的传出纤维分布于中央灰质、中缝核、腹侧被盖区和网状结构。内侧视前区的投射还通过终纹到达杏仁核，通过髓纹到达外侧缰核，以及到达室周丘脑。最内侧和室周视前区（pvPOA）神经元的轴突分布与更外侧的内侧视前区神经元相似，但其最长轴突投射较弱。室周视前区不通过髓纹发出轴突，但与更外侧的内侧视前区相比，其向弓状核和正中隆起的投射更为密集。终纹床核（nST）的投射在大多数方面与内侧视前区的相似，主要增加了一条至副嗅球的投射。布罗卡斜角带核（nDBB）的投射模式与内侧视前区或终纹床核不同，例如，它投射至内侧隔区和海马。布罗卡斜角带核的下行传出纤维走行于内侧前脑束的腹侧部分。在下丘脑细胞群中，只有内侧乳头体核接受布罗卡斜角带核的投射。布罗卡斜角带核的传出纤维也分布于内侧和外侧缰核以及丘脑背内侧核。
