Santilli S M, Stevens R B, Anderson J G, Caldwell M D
Department of Surgery, University of Minnesota Hospital and Clinics, Minneapolis 55455, USA.
Ann Vasc Surg. 1995 Mar;9(2):146-51. doi: 10.1007/BF02139656.
Atherosclerosis is associated with aging based on numerous epidemiologic studies, whereas arterial wall hypoxia has been associated with other risk factors for atherosclerosis. We studied the effect of age on the transarterial wall oxygen gradient in the rat using an oxygen microelectrode. A decrease in oxygen tension in the outer 35% of the artery wall was noted in 36- to 40-week-old rats when compared to 3- to 4-week-old rats. These findings were noted despite no difference in arterial blood oxygen tension between the two groups and prior to any histologic evidence of atherosclerotic lesion formation. Our observations suggest that aging decreases the delivery of oxygen to the outer artery wall.
基于众多流行病学研究，动脉粥样硬化与衰老相关，而动脉壁缺氧与动脉粥样硬化的其他危险因素相关。我们使用氧微电极研究了年龄对大鼠经动脉壁氧梯度的影响。与3至4周龄的大鼠相比，在36至40周龄的大鼠中发现动脉壁外层35%的氧张力降低。尽管两组之间动脉血氧张力没有差异，且在动脉粥样硬化病变形成的任何组织学证据出现之前，就已观察到这些结果。我们的观察结果表明，衰老会减少氧气向动脉壁外层的输送。
