Santilli S M, Wernsing S E, Lee E S
Department of Surgery, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA.
Ann Vasc Surg. 2001 Jul;15(4):435-42. doi: 10.1007/s100160010119.
Artery wall hypoxia has been proposed to contribute to many kinds of artery wall pathology, including atherosclerosis and intimal hyperplasia. The purpose of this study was to determine the effect of supplemental oxygen on the transarterial wall oxygen gradients at a prosthetic vascular device (PVG)-to-artery anastomosis. The transarterial wall oxygen gradient in the infrarenal aorta of New Zealand White rabbits housed for 42 days in a 40% supplemental oxygen was measured with an oxygen microelectrode 2 mm distal to a PVG-to-artery anastomosis. Oxygen tensions were significantly increased throughout the artery wall at all time points in the supplemental oxygen groups compared to those in non-oxygen-supplemented groups. Within the oxygen-supplemented groups, the outer artery wall had diminished oxygen tensions immediately following creation of the anastomosis, with a slow return to control oxygen tensions on postanastomosis day 42 which correlated with a return of the vasa vasorum. These changes were noted without differences in blood pressure or arterial blood oxygen concentrations within the oxygen-supplemented group. Artery wall hypoxia noted following the creation of a PVG-to-artery anastomosis can be eliminated and artery wall oxygen tensions significantly increased by the administration of supplemental oxygen.
动脉壁缺氧被认为与多种动脉壁病变有关，包括动脉粥样硬化和内膜增生。本研究的目的是确定补充氧气对人工血管装置（PVG）与动脉吻合处跨动脉壁氧梯度的影响。使用氧微电极在新西兰白兔的肾下腹主动脉中，于PVG与动脉吻合处远端2mm处测量了在40%补充氧气环境中饲养42天的动物的跨动脉壁氧梯度。与未补充氧气的组相比，补充氧气组在所有时间点整个动脉壁的氧分压均显著升高。在补充氧气组中，吻合术后即刻动脉壁外层的氧分压降低，在吻合术后第42天缓慢恢复至对照氧分压，这与滋养血管的恢复相关。在补充氧气组中，血压或动脉血氧浓度无差异的情况下观察到了这些变化。PVG与动脉吻合术后出现的动脉壁缺氧可通过补充氧气消除，且动脉壁氧分压显著升高。
