Santilli S M, Stevens R B, Anderson J G, Payne W D, Caldwell M D
Department of Surgery, University of Minnesota Hospital and Clinic, Minneapolis 55455.
Am J Physiol. 1995 Jan;268(1 Pt 2):H155-61. doi: 10.1152/ajpheart.1995.268.1.H155.
The purpose of this study was to determine the effect of the carotid artery bifurcation on the delivery of oxygen to the artery wall by measuring the transarterial wall oxygen gradient. Transarterial wall oxygen gradient measurements were performed in dogs anesthetized with thiopental sodium and isoflurane by means of an oxygen microelectrode. Measurements were performed at six locations along the carotid bifurcation. Oxygen tensions at the carotid sinus were decreased in the inner 40% of the artery wall compared with control locations. Oxygen tensions at the flow divider were increased throughout the artery wall compared with control locations. These effects were noted without differences in blood pressure, arterial blood oxygen tension, or histological evidence of atherosclerotic lesion formation. These findings suggest that the delivery of oxygen to the artery wall is altered by the bifurcation of the carotid artery. Low arterial oxygen tensions at the carotid sinus support a role for artery wall hypoxia in the formation of atherosclerotic lesions.
本研究的目的是通过测量经动脉壁的氧梯度，确定颈动脉分叉对氧输送至动脉壁的影响。通过氧微电极对用硫喷妥钠和异氟烷麻醉的犬进行经动脉壁氧梯度测量。在沿颈动脉分叉的六个位置进行测量。与对照位置相比，动脉壁内侧40%处的颈动脉窦氧张力降低。与对照位置相比，分流器处整个动脉壁的氧张力升高。在血压、动脉血氧张力或动脉粥样硬化病变形成的组织学证据方面未发现差异的情况下观察到了这些效应。这些发现表明，颈动脉分叉会改变氧向动脉壁的输送。颈动脉窦处低动脉氧张力支持动脉壁缺氧在动脉粥样硬化病变形成中的作用。
