Makarov V L, Kuznetsov S R
I.P. Pavlov Institute of Physiology, Russian Academy of Sciences, St.-Petersburg.
Int J Exp Pathol. 1995 Apr;76(2):93-6.
Na+,L(+)-pump activity, intracellular sodium, potassium and magnesium concentrations and membrane cholesterol content were studied in erythrocytes of rabbits fed cholesterol. The average activity of the Na+,K(+)-pump in erythrocytes of rabbits with high plasma cholesterol was twice that in erythrocytes of control animals. Analysis showed a positive correlation between the pump activity and plasma cholesterol. The sodium content in erythrocytes correlated negatively with plasma cholesterol, as well as with the Na+,K(+)-pump activity. No significant differences in potassium and magnesium concentrations or in the membrane cholesterol content were observed between the two groups. The results indicate that modulation of the pump activity by cholesterol is not necessarily mediated by changes in the membrane viscosity.
研究了喂食胆固醇的家兔红细胞中的钠、L(+)-泵活性、细胞内钠、钾和镁浓度以及膜胆固醇含量。血浆胆固醇高的家兔红细胞中钠、钾-泵的平均活性是对照动物红细胞的两倍。分析表明泵活性与血浆胆固醇之间呈正相关。红细胞中的钠含量与血浆胆固醇以及钠、钾-泵活性呈负相关。两组之间在钾和镁浓度或膜胆固醇含量方面未观察到显著差异。结果表明，胆固醇对泵活性的调节不一定是由膜粘度的变化介导的。
