Vaccarino F J, Mogil J S, Stinus L
Department of Psychology, University of Toronto, Ontario, Canada.
J Psychiatry Neurosci. 1995 May;20(3):210-4.
Chronic interference with dopamine (DA) transmission has been found to facilitate opiate reward and opiate-induced behavioral activation derived from the nucleus accumbens. This study was aimed at determining the extent to which these effects are generalizable to opiate-induced feeding. Rats were tested for their feeding response to morphine following chronic interference with DAergic transmission with the long-acting neuroleptic, flupenthixol decanoate (FLU). It was found that FLU-treated animals showed an enhanced feeding response to morphine following three and four weeks of DA blockade, but not on weeks 1 and 2. Neither morphine treatment in FLU-control animals nor chronic FLU treatment alone produced any such time-dependent facilitation in feeding. The results indicate that the increased sensitivity to the rewarding effects of opiates following chronic DA blockade is generalizable to opiate-induced feeding.
研究发现，长期干扰多巴胺（DA）传递可促进伏隔核产生的阿片类奖赏效应以及阿片类诱导的行为激活。本研究旨在确定这些效应在多大程度上可推广至阿片类诱导的进食行为。用长效抗精神病药物癸酸氟奋乃静（FLU）长期干扰多巴胺能传递后，测试大鼠对吗啡的进食反应。结果发现，在多巴胺阻断3周和4周后，接受FLU治疗的动物对吗啡的进食反应增强，但在第1周和第2周未出现这种情况。FLU对照动物接受吗啡治疗或单独进行长期FLU治疗，均未产生任何这种随时间变化的进食促进作用。结果表明，长期多巴胺阻断后对阿片类奖赏效应敏感性增加这一现象，可推广至阿片类诱导的进食行为。
