一类参数激励钙振荡探测器。
A class of parametrically excited calcium oscillation detectors.
作者信息
Izu L T, Spangler R A
机构信息
Department of Physiology, State University of New York at Buffalo 14214, USA.
出版信息
Biophys J. 1995 Apr;68(4):1621-9. doi: 10.1016/S0006-3495(95)80337-1.
Intracellular Ca2+ oscillations are often a response to external signals such as hormones. Changes in the external signal can alter the frequency, amplitude, or form of the oscillations suggesting that information is encoded in the pattern of Ca2+ oscillations. How might a cell decode this signal? We show that an excitable system whose kinetic parameters are modulated by the Ca2+ concentration can function as a Ca2+ oscillation detector. Such systems have the following properties: (1) They are more sensitive to an oscillatory than to a steady Ca2+ signal. (2) Their response is largely independent of the signal amplitude. (3) They can extract information from a noisy signal. (4) Unlike other frequency sensitive detectors, they have a flat frequency response. These properties make a Ca(2+)-sensitive excitable system nearly ideal for detecting and decoding Ca2+ oscillations. We suggest that Ca2+ oscillations, in concert with these detectors, can act as cellular timekeepers to coordinate related biochemical reactions and enhance their overall efficiency.
细胞内钙离子振荡通常是对诸如激素等外部信号的一种反应。外部信号的变化能够改变振荡的频率、幅度或形式，这表明信息被编码在钙离子振荡模式中。细胞如何解码这个信号呢？我们表明，一个其动力学参数受钙离子浓度调节的可兴奋系统能够充当钙离子振荡探测器。这样的系统具有以下特性：（1）它们对振荡信号比对稳定的钙离子信号更敏感。（2）它们的反应在很大程度上独立于信号幅度。（3）它们能够从有噪声的信号中提取信息。（4）与其他频率敏感探测器不同，它们具有平坦的频率响应。这些特性使得一个对钙离子敏感的可兴奋系统几乎成为检测和解码钙离子振荡的理想选择。我们认为，钙离子振荡与这些探测器协同作用，可以充当细胞的计时器，以协调相关的生化反应并提高其整体效率。
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