Ontell M, Ontell M P, Buckingham M
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA.
Microsc Res Tech. 1995 Apr 1;30(5):354-65. doi: 10.1002/jemt.1070300503.
Over the past decade, significant advances in molecular biological techniques have substantially increased our understanding of in vivo myogenesis, supplementing the information that previously had been obtained from classical embryological and morphological studies of muscle development. In this review, we have attempted to correlate morphogenetic events in developing murine muscle with the expression of genes encoding the MyoD family of myogenic regulatory factors and the contractile proteins. Differences in the pattern of expression of these genes in murine myotomal and limb muscle are discussed in the context of muscle cell lineage and environmental factors. The differences in gene expression in these two types of muscle suggest that no single coordinated pattern of gene activation is required during the initial formation of the muscles of the mouse.
在过去十年中，分子生物学技术取得了重大进展，极大地增进了我们对体内肌生成的理解，补充了先前从肌肉发育的经典胚胎学和形态学研究中获得的信息。在这篇综述中，我们试图将发育中小鼠肌肉的形态发生事件与编码肌源性调节因子MyoD家族和收缩蛋白的基因表达联系起来。在肌肉细胞谱系和环境因素的背景下，讨论了这些基因在小鼠肌节和肢体肌肉中表达模式的差异。这两种类型肌肉中基因表达的差异表明，在小鼠肌肉的初始形成过程中，不需要单一协调的基因激活模式。
