Radetti G, Paganini C, Crepaz R, Pittscheider W, Gentili L
Department of Paediatrics, Regional Hospital of Bolzano, Italy.
Eur J Endocrinol. 1995 Jun;132(6):688-92. doi: 10.1530/eje.0.1320688.
Morphology and function of the left ventricle were evaluated by echo and Doppler examination in 16 females affected by Hashimoto's thyroiditis, aged 13.3 (4.5) years (range 7.9-24.6). They were on L-thyroxine (L-T4) treatment for a period of 2.8 (2.8) years (range 0.8-7.6) with a mean daily dose of 77 (18) micrograms/m2. Left ventricular mass, systolic and diastolic function, cardiac output and systemic vascular resistance did not differ from a control group matched for age, sex and body size. A further analysis of the patients according to thyrotrophin serum levels (less or more than 0.1 mU/l) gave similar results. Moreover, no relationship was found between echocardiographic findings and age, L-T4 daily doses, duration of treatment and serum level of thyroid hormones. We can therefore conclude that chronic L-T4 treatment for Hashimoto's thyroiditis at the given doses did not affect cardiac function and morphology in children and adolescents; however, a longer follow-up is needed before confirming the safety of this therapy in the long term.
通过超声心动图和多普勒检查评估了16例患桥本甲状腺炎的女性的左心室形态和功能，这些女性年龄为13.3（4.5）岁（范围7.9 - 24.6岁）。她们接受左甲状腺素（L - T4）治疗2.8（2.8）年（范围0.8 - 7.6年），平均每日剂量为77（18）微克/平方米。左心室质量、收缩和舒张功能、心输出量及体循环血管阻力与年龄、性别和体型相匹配的对照组无差异。根据促甲状腺激素血清水平（低于或高于0.1 mU/l）对患者进行进一步分析，结果相似。此外，超声心动图检查结果与年龄、L - T4每日剂量、治疗持续时间及甲状腺激素血清水平之间未发现相关性。因此我们可以得出结论，以给定剂量对桥本甲状腺炎进行慢性L - T4治疗，不会影响儿童和青少年的心脏功能和形态；然而，在确认该疗法长期安全性之前，还需要更长时间的随访。
