Radetti G, Castellan C, Tatò L, Platter K, Gentili L, Adami S
Department of Pediatrics, General Hospital of Bolzano, Italy.
Horm Res. 1993;39(3-4):127-31. doi: 10.1159/000182712.
Single-photon absorptiometry was used to assess forearm bone mineral content (BMC) at a proximal site (PBMC) and at a more distal site (DBMC) of the non-dominant distal forearm in 20 children and adolescent females taking high doses of L-thyroxine (120 micrograms/m2/day) for a period of 6-96 months for endemic goiter, Hashimoto's thyroiditis or thyroid cancer. PBMC was significantly reduced compared to controls (p < 0.002). No correlation was found between PBMC, the values of circulating thyroid hormones and the indices of tissue hyperthyroidism such as TSH and systolic time intervals (STI), suggesting that bone is a very sensitive target for thyroid hormones. Further studies are necessary to confirm our findings and to verify their clinical significance. At present, we believe that suppressive doses of L-thyroxine should be reserved for cancer patients only.
采用单光子吸收法，对20名因地方性甲状腺肿、桥本甲状腺炎或甲状腺癌而长期（6 - 96个月）服用高剂量L-甲状腺素（120微克/平方米/天）的儿童及青春期女性非优势侧前臂近端（近端骨矿物质含量，PBMC）和更远端部位（远端骨矿物质含量，DBMC）的前臂骨矿物质含量（BMC）进行评估。与对照组相比，PBMC显著降低（p < 0.002）。未发现PBMC、循环甲状腺激素值与组织甲状腺功能亢进指标（如促甲状腺激素和收缩期时间间期，STI）之间存在相关性，这表明骨骼是甲状腺激素非常敏感的靶点。需要进一步研究以证实我们的发现并验证其临床意义。目前，我们认为仅应将抑制剂量的L-甲状腺素用于癌症患者。
