Tanaka T, Fujita M, Fudo T, Tamaki S, Nohara R, Sasayama S
Takeda Hospital, College of Medical Technology, Japan.
Coron Artery Dis. 1995 Mar;6(3):241-4.
The effects of diabetes mellitus and its treatment on the circadian variation of symptom onset in acute myocardial infarction were examined.
We obtained the time of symptom onset in 336 patients who had suffered acute myocardial infarction.
As in earlier studies, the peak of symptom onset occurred in the late morning, between 6:01 a.m. and 12:00 noon. Although a similar circadian variation was observed in non-diabetic patients, the late-morning peak was less prominent in diabetic patients. In diabetic patients receiving treatment, however, the circadian pattern was well preserved, whereas in untreated diabetic patients there were no peaks in the distribution of symptom onset of acute myocardial infarction.
These findings suggest that autonomic disturbances in diabetes mellitus may blunt the late-morning peak in the frequency of onset of acute myocardial infarction.
研究了糖尿病及其治疗对急性心肌梗死症状发作昼夜变化的影响。
我们获取了336例急性心肌梗死患者的症状发作时间。
与早期研究一样，症状发作高峰出现在上午晚些时候，即上午6:01至中午12:00之间。虽然在非糖尿病患者中观察到类似的昼夜变化，但糖尿病患者的上午晚些时候高峰不太明显。然而，在接受治疗的糖尿病患者中，昼夜模式保存良好，而在未治疗的糖尿病患者中，急性心肌梗死症状发作分布没有高峰。
这些发现表明，糖尿病中的自主神经紊乱可能会减弱急性心肌梗死发作频率的上午晚些时候高峰。
