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Intrahippocampal NMDA Administration Alters Fos, Fos-Related Antigens, and Opioid Peptide Immunoreactivity and mRNA in Rats.海马内 NMDA 给药改变大鼠的 Fos、Fos 相关抗原和阿片肽免疫反应性和 mRNA。
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Evidence for the co-expression of oxytocin and vasopressin messenger ribonucleic acids in magnocellular neurosecretory cells: simultaneous demonstration of two neurohypophysin messenger ribonucleic acids by hybridization histochemistry.证明大细胞神经分泌细胞中催产素和血管加压素信使核糖核酸的共表达：通过杂交组织化学同时证明两种神经垂体信使核糖核酸的存在。
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Stressor controllability, social interaction, and benzodiazepine systems.应激源可控性、社会互动与苯二氮䓬系统。
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Chronic brief restraint decreases in vivo binding of benzodiazepine receptor ligand to mouse brain.慢性短暂束缚会降低苯二氮䓬受体配体与小鼠脑的体内结合。
Mol Chem Neuropathol. 1993 Jan-Feb;18(1-2):115-21. doi: 10.1007/BF03160025.
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Restraint stress-induced changes in endogenous zinc release from the rat hippocampus.束缚应激诱导大鼠海马体内源性锌释放的变化。
Brain Res. 1993 Aug 6;618(2):318-22. doi: 10.1016/0006-8993(93)91283-x.
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Induction of the c-fos proto-oncogene in the rat pineal gland during stress.
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Short inescapable stress produces long-lasting changes in the brain-pituitary-adrenal axis of adult male rats.
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Chlordiazepoxide attenuates stress-induced accumulation of corticotropin-releasing factor mRNA in the paraventricular nucleus.
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Induction of c-fos mRNA in the brain and anterior pituitary gland by a novel environment.
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Hippocampal 5-HT receptors and consolidation of stressful memories.海马体5-羟色胺受体与应激记忆的巩固
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咪达唑仑和N-甲基-D-天冬氨酸（NMDA）受体拮抗剂2-氨基-7-磷酸庚酸（AP-7）可减弱应激诱导的齿状回中c-fos mRNA的表达。

Midazolam and the N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-7-phosphonoheptanoic acid (AP-7) attenuate stress-induced expression of c-fos mRNA in the dentate gyrus.

作者信息

Titze-de-Almeida R, de Oliveira C L, Shida H W, Guimarães F S, Del Bel E A

机构信息

Department of Pharmacology, School of Medicine, Ribeirão Preto, SP, Brazil.

出版信息

Cell Mol Neurobiol. 1994 Aug;14(4):373-80. doi: 10.1007/BF02088717.

DOI:10.1007/BF02088717
PMID:7788644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11566790/
Abstract
  1. The effects of restraint stress on c-fos mRNA expression in the dentate gyrus were investigated by in situ hybridization. 2. Confirming previous findings, c-fos mRNA expression increased after 30 min of forced restraint. 3. This effect was attenuated by a previous i.c.v. injection of the anxiolytic benzodiazepine midazolam (20 nmol/2 microliters) or the N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-7-phosphonoheptanoic acid (AP-7; 5 nmol/2 microliters). 4. These results suggest that the dentate gyrus is activated during restraint stress and that this activation may be modulated by benzodiazepine gamma-aminobutyric acidA (GABAA) or NMDA receptors.
摘要
  1. 通过原位杂交研究了束缚应激对齿状回中c-fos mRNA表达的影响。2. 证实了先前的研究结果，强迫束缚30分钟后c-fos mRNA表达增加。3. 这种效应被先前脑室内注射抗焦虑苯二氮䓬类咪达唑仑（20纳摩尔/2微升）或N-甲基-D-天冬氨酸（NMDA）受体拮抗剂2-氨基-7-磷酸庚酸（AP-7；5纳摩尔/2微升）所减弱。4. 这些结果表明，在束缚应激期间齿状回被激活，并且这种激活可能受苯二氮䓬γ-氨基丁酸A（GABAA）或NMDA受体调节。