通过荧光原位杂交对五种非人类灵长类动物的免疫球蛋白Cε1基因（IGHE）进行比较定位。

Comparative mapping of the immunoglobulin C epsilon 1 gene (IGHE) in five species of nonhuman primates by fluorescence in situ hybridization.

作者信息

Tanabe H, Ishida T, Ueda S, Sofuni T, Mizusawa H

机构信息

Laboratory of Cell Bank, National Institute of Health Sciences, Tokyo, Japan.

出版信息

Cytogenet Cell Genet. 1995;70(3-4):239-42. doi: 10.1159/000134042.

DOI:10.1159/000134042

PMID:7789180

Abstract

The orthologous immunoglobulin C epsilon 1 gene (IGHE) of the common chimpanzee, pygmy chimpanzee, orangutan, white-handed gibbon, and Japanese macaque was assigned to the human chromosome 14 homologue in each species and regionally mapped by fluorescence in situ hybridization to PTR15q32 (common chimpanzee), PPA15q32 (pygmy chimpanzee), PPY15q32 (orangutan), HLA17qter (white-handed gibbon), and MFU7q29 (Japanese macaque). The gene localized to the terminal region of the chromosome in each species, and so this probe provides a new telomeric DNA marker for nonhuman primates.

摘要

将黑猩猩、倭黑猩猩、猩猩、白掌长臂猿和日本猕猴的直系同源免疫球蛋白Cε1基因（IGHE）定位到每个物种中与人类14号染色体同源的染色体上，并通过荧光原位杂交在区域上进行定位，结果如下：普通黑猩猩位于PTR15q32，倭黑猩猩位于PPA15q32，猩猩位于PPY15q32，白掌长臂猿位于HLA17qter，日本猕猴位于MFU7q29。该基因在每个物种中都定位于染色体的末端区域，因此该探针为非人类灵长类动物提供了一种新的端粒DNA标记。