全身给予GM1神经节苷脂可增加老年大鼠大脑中的胆碱乙酰转移酶活性。
Systemic administration of GM1 ganglioside increases choline acetyltransferase activity in the brain of aged rats.
作者信息
Fong T G, Neff N H, Hadjiconstantinou M
机构信息
Department of Pharmacology, Ohio State University, College of Medicine, Columbus 43210, USA.
出版信息
Exp Neurol. 1995 Apr;132(2):157-61. doi: 10.1016/0014-4886(95)90020-9.
In the brain of aged rats (22-24 months old) choline acetyltransferase (ChAT) activity in striatum and frontal cortex is lower than in young rats (4-5 months old). In contrast, ChAT activity in the hippocampus is similar in the two groups. Treating old animals with GM1 ganglioside, 30 mg/kg ip, for 30 or 45 days enhances ChAT activity in the striatum and frontal cortex, but has no effect on activity in the hippocampus. ChAT activity remains elevated in the striatum and frontal cortex for 15 days after discontinuing treatment with GM1.
在老年大鼠（22 - 24月龄）的大脑中，纹状体和额叶皮质中的胆碱乙酰转移酶（ChAT）活性低于年轻大鼠（4 - 5月龄）。相比之下，两组大鼠海马体中的ChAT活性相似。用30mg/kg的GM1神经节苷脂腹腔注射处理老年动物30天或45天，可增强纹状体和额叶皮质中的ChAT活性，但对海马体中的活性没有影响。停止GM1处理后15天，纹状体和额叶皮质中的ChAT活性仍保持升高。
Zotero 插件