Gürgan T, Urman B, Yarali H, Kişnişçi H A
Department of Obstetrics and Gynecology, University of Hacettepe, Ankara, Turkey.
Fertil Steril. 1995 Jul;64(1):93-7.
To determine the results of IVF-ET in couples with long-standing unexplained infertility who had failed to conceive with four to six cycles of superovulation and IUI.
Retrospective case control series.
University IVF-ET center.
One hundred seventeen couples with unexplained infertility who had failed to conceive with superovulation and IUI underwent 157 cycles of IVF-ET. Results were compared with 194 tubal factor couples subjected to 250 IVF-ET cycles within the same time period.
Total fertilization failure events were more common (20.4% versus 7.6%) and tended to be repetitive in couples with unexplained infertility. When total fertilization failure events were excluded, fertilization rates (57.8% versus 60.9%) and cumulative clinical pregnancy rates over three cycles (55.4% versus 46.5%) were similar in unexplained infertility and tubal disease groups.
Couples with unexplained infertility failing to conceive with superovulation and IUI have a favorable outcome when treated subsequently with IVF-ET. Conception rates similar to couples with tubal disease may be expected despite a higher incidence of total fertilization failure events.
确定对于长期不明原因不孕且经4至6个周期超排卵和宫腔内人工授精（IUI）仍未受孕的夫妇，体外受精-胚胎移植（IVF-ET）的结果。
回顾性病例对照系列研究。
大学IVF-ET中心。
117对不明原因不孕且经超排卵和IUI仍未受孕的夫妇接受了157个周期的IVF-ET。将结果与同期接受250个周期IVF-ET的194对输卵管因素不孕夫妇进行比较。
完全受精失败事件在不明原因不孕夫妇中更常见（20.4%对7.6%），且往往具有重复性。排除完全受精失败事件后，不明原因不孕组和输卵管疾病组的受精率（57.8%对60.9%）以及三个周期内的累积临床妊娠率（55.4%对46.5%）相似。
对于经超排卵和IUI仍未受孕的不明原因不孕夫妇，随后接受IVF-ET治疗会有良好结局。尽管完全受精失败事件发生率较高，但预期受孕率与输卵管疾病夫妇相似。
Zotero 插件