Manabe A, Hata T, Kitao M
Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan.
Gynecol Obstet Invest. 1995;39(3):171-9. doi: 10.1159/000292403.
The objective of this longitudinal study was to evaluate alterations in regional vascular resistance of arteries with advancing gestation in normal and growth-retarded fetuses. Color Doppler flow imaging and pulsed Doppler ultrasonographic assessments were performed on 13 normal and 7 growth-retarded fetuses, ranging from 15 to 40 weeks menstrual age. The pulsatility index was calculated for middle cerebral artery, descending aorta, splenic artery, renal artery, femoral artery and umbilical artery, respectively. Optimal models for these pulsatility index values were determined by regression analysis. A normal range of the pulsatility index for each artery generated in the normal fetuses. In the middle cerebral artery, the models showed a parabolic pattern during pregnancy in the two groups and the predicted pulsatility index values in growth-retarded fetuses were always lower than those in the normal fetuses, especially late in pregnancy. In the renal artery, the predicted pulsatility index values in growth-retarded fetuses were higher than those in normal fetuses near term. In other arteries, the predicted pulsatility index values showed their own specific patterns and there were no significant differences in predicted pulsatility index values in the two groups. In conclusion, alterations in regional vascular resistance of arteries with advancing menstrual age occur evidenced in both normal and growth-retarded fetuses.
这项纵向研究的目的是评估正常胎儿和生长受限胎儿随着孕周增加动脉区域血管阻力的变化。对13例正常胎儿和7例生长受限胎儿进行了彩色多普勒血流成像和脉冲多普勒超声评估，孕龄范围为15至40周。分别计算大脑中动脉、降主动脉、脾动脉、肾动脉、股动脉和脐动脉的搏动指数。通过回归分析确定这些搏动指数值的最佳模型。得出正常胎儿各动脉搏动指数的正常范围。在大脑中动脉，两组模型在孕期均呈抛物线模式，生长受限胎儿的预测搏动指数值始终低于正常胎儿，尤其是在孕晚期。在肾动脉，接近足月时生长受限胎儿的预测搏动指数值高于正常胎儿。在其他动脉，预测搏动指数值呈现各自的特定模式，两组预测搏动指数值无显著差异。总之，正常胎儿和生长受限胎儿均显示随着孕龄增加动脉区域血管阻力发生变化。
