人类22号染色体上的β-晶状体蛋白基因定义了一个与小鼠5号染色体同源的新区域。
The beta crystallin genes on human chromosome 22 define a new region of homology with mouse chromosome 5.
作者信息
Hulsebos T J, Jenkins N A, Gilbert D J, Copeland N G
机构信息
Institute of Human Genetics, University of Amsterdam, The Netherlands.
出版信息
Genomics. 1995 Jan 20;25(2):574-6. doi: 10.1016/0888-7543(95)80062-q.
The human beta crystallin genes CRYBB2, CRYBB2P1, CRYBB3, and CRYBA4 are located in 22q11.2. Using interspecific backcross analysis, we mapped the mouse homologues of CRYBB2, CRYBB3, and CRYBA4 (i.e., Crybb2, Crybb3, and Cryba4) to the central region of mouse chromosome 5. The homologue of human CRYBB2P1 is absent in mouse. These assignments define a new region of homology in human and mouse.
人类β-晶体蛋白基因CRYBB2、CRYBB2P1、CRYBB3和CRYBA4位于22q11.2。通过种间回交分析，我们将CRYBB2、CRYBB3和CRYBA4的小鼠同源基因（即Crybb2、Crybb3和Cryba4）定位到小鼠5号染色体的中央区域。小鼠中不存在人类CRYBB2P1的同源基因。这些定位确定了人类和小鼠新的同源区域。
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