Baneth G, Harmelin A, Presentey B Z
Koret School of Veterinary Medicine, Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot, Israel.
J Am Vet Med Assoc. 1995 Jun 15;206(12):1891-4.
Infection of 60 to 90% of neutrophils with the protozoa, Hepatozoon canis, was detected in 2 dogs. Clinical signs included lethargy, anorexia, and weight loss. Both dogs had severe anemia, leukocytosis, and thrombocytopenia as well as hypoalbuminemia, hyperglobulinemia, and high activities of serum alkaline phosphatase and creatine kinase. Both dogs were treated with imidocarb dipropionate and doxycycline. One dog recovered clinically, with disappearance of parasites from WBC. The other dog died, despite treatment. Necropsy revealed widespread dispersion of schizonts in the parenchymal tissues, but no involvement of skeletal muscle tissues. The disease syndrome that has been identified in the Texas Gulf region is characterized by gait abnormalities associated with multifocal pyogranulomatous myositis, thus, it is distinct clinicopathologically from the syndrome observed in these 2 dogs.
在2只犬中检测到60%至90%的中性粒细胞被犬肝簇虫这种原生动物感染。临床症状包括嗜睡、厌食和体重减轻。两只犬均有严重贫血、白细胞增多、血小板减少以及低白蛋白血症、高球蛋白血症，血清碱性磷酸酶和肌酸激酶活性升高。两只犬均接受了双丙酸咪唑苯脲和强力霉素治疗。一只犬临床康复，白细胞中寄生虫消失。另一只犬尽管接受了治疗仍死亡。尸检显示裂殖体广泛散布于实质组织中，但骨骼肌组织未受累。在得克萨斯湾地区发现的疾病综合征的特征是与多灶性脓性肉芽肿性肌炎相关的步态异常，因此，在临床病理学上与这2只犬所观察到的综合征不同。
