Toftegaard M, Knudsen F
Department of Anaesthesia and Intensive Care, Aalborg Hospital, Denmark.
Intensive Care Med. 1995 Mar;21(3):238-40. doi: 10.1007/BF01701480.
A case of severe polyuria elicited by intravenous administration of a normal pharmacological dose of dexamethasone is reported. The polyuria did not respond to treatment with vasopressin. A 15-year-old girl with a brain tumour was referred for surgery. After induction of anaesthesia she received dexamethasone 4 mg i.v., and developed a massive polyuria with hourly diuresis of up to 1250 ml. There was no response to treatment with vasopressin in doses well above those normally used. The patient did not fulfil any known cause of diabetes insipidus, and to our best knowledge, this case is the first with glucocorticoid-induced and vasopressin-resistant polyuria ever reported in man.
报告了一例静脉注射正常药理剂量地塞米松引发严重多尿的病例。该多尿对血管加压素治疗无反应。一名患有脑肿瘤的15岁女孩被转诊接受手术。麻醉诱导后，她静脉注射了4毫克地塞米松，随后出现大量多尿，每小时尿量高达1250毫升。使用远高于正常剂量的血管加压素治疗也无反应。该患者不符合任何已知的尿崩症病因，据我们所知，此病例是首例人类中报道的糖皮质激素诱导且对血管加压素耐药的多尿症。
