Scelsi R, Scelsi L, Cortinovis R, Poggi P
Department of Human Pathology, University of Pavia, Italy.
Int Angiol. 1994 Dec;13(4):308-11.
Morphological changes of dermal blood and lymphatic microcirculation in skin biopsies from patients affected by Chronic Venous Insufficiency (CVI) associated with stasis dermatitis of the lower limbs, are reported here. Blood vessels are characterized by an occluded lumen, thickening and reduplication of the basement membrane. The structural changes in dermal lymphatic vessels are: (i) collapsed lumen of lymphatics located in the papillar dermis; (ii) numerous and complex interdigitations between contiguous endothelial cells and lack of open junctions; (iii) derangement of the anchoring filaments that normally pull the lymphatic lumen open. The connective matrix is characterized by fibrosis with formation of dense bundles of collagen and elastic fibers. These results suggest that the dermal lymphatic and blood microcirculation in CVI are connected to a reduced fluid exchange capacity because of the structural changes occurred in the vascular and lymphatic wall and in the surrounding connective tissue.
本文报道了慢性静脉功能不全（CVI）合并下肢淤积性皮炎患者皮肤活检中真皮血液和淋巴微循环的形态学变化。血管的特征为管腔闭塞、基底膜增厚和重复。真皮淋巴管的结构变化包括：（i）位于乳头层真皮的淋巴管管腔塌陷；（ii）相邻内皮细胞之间有大量复杂的指状交叉且无开放连接；（iii）正常情况下拉开淋巴管腔的锚定丝排列紊乱。结缔组织基质的特征是纤维化，形成致密的胶原纤维束和弹性纤维束。这些结果表明，由于血管和淋巴管壁以及周围结缔组织发生的结构变化，CVI中的真皮淋巴和血液微循环与液体交换能力降低有关。
