Cameron H A, McEwen B S, Gould E
Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA.
J Neurosci. 1995 Jun;15(6):4687-92. doi: 10.1523/JNEUROSCI.15-06-04687.1995.
The effects of afferent input and N-methyl-D-aspartate (NMDA) receptor activation on neurogenesis were examined in an intact system, the rat dentate gyrus, where neurons are naturally born in the adult. In the adult dentate gyrus, activation of NMDA receptors rapidly decreased the number of cells synthesizing DNA, whereas blockade of NMDA receptors rapidly increased the number of cells in the S phase identified with 3H-thymidine. Acute treatment with NMDA receptor antagonists increased the birth of neurons and increased the overall density of neurons in the granule cell layer. Lesion of the entorhinal cortex, the main excitatory afferent population to the granule neurons, also increased the birth of cells in the dentate gyrus. These results suggest that adult neurogenesis in the dentate gyrus of the rat is altered by afferent input, via NMDA receptors, and may be regulated naturally by endogenous excitatory amino acids.
在一个完整的系统——成年大鼠齿状回（成年个体中神经元自然生成的部位）中，研究了传入输入和N-甲基-D-天冬氨酸（NMDA）受体激活对神经发生的影响。在成年大鼠齿状回中，NMDA受体的激活迅速减少了合成DNA的细胞数量，而NMDA受体的阻断则迅速增加了用3H-胸腺嘧啶核苷鉴定的S期细胞数量。用NMDA受体拮抗剂进行急性处理增加了神经元的生成，并增加了颗粒细胞层中神经元的总体密度。内嗅皮质（颗粒神经元的主要兴奋性传入群体）的损伤也增加了齿状回中细胞的生成。这些结果表明，大鼠齿状回中的成年神经发生通过NMDA受体受到传入输入的影响，并且可能受到内源性兴奋性氨基酸的自然调节。
