Laihinen A O, Rinne J O, Någren K A, Lehikoinen P K, Oikonen V J, Ruotsalainen U H, Ruottinen H M, Rinne U K
Department of Neurology, University of Turku, Finland.
J Nucl Med. 1995 Jul;36(7):1263-7.
The cocaine analog 2 beta-carbomethoxy-3 beta-[4-iodophenyl]tropane (beta-CIT) labeled with 11C was used to study dopamine reuptake sites with PET.
Three normal subjects and nine patients with Parkinson's disease were investigated. Each of them underwent a dynamic PET scan (25 timeframes over 80 min) with [11C]-beta-CIT. A dose of 102.5-211.3 MBq (2.77-5.71 mCi) of this ligand was administered intravenously and a PET examination with an ECAT 931/08 PET camera was carried out. Ratios between the striatal/cortical/thalamic/midbrain and cerebellar uptake of this radioligand were calculated.
The highest accumulation of [11C]beta-CIT was observed in the caudate and putamen, though there was some uptake in the thalamus and the midbrain. Cortical uptake was negligible. Carbon-11-beta-CIT accumulated significantly less in the putamen of the Parkinson's patients than in the normal subjects. The putamen-to-cerebellum ratio in the Parkinson's patients was 1.59 +/- 0.04 and 1.80 +/- 0.13s (p = 0.028) in the normal subjects. In the caudate, there was no significant difference between the Parkinson's patients and the normal subjects.
These results imply that [11C]beta-CIT is a useful compound for carrying out a PET examination of the function of the presynaptic monoaminergic neurons both in normal and pathological brains.
用11C标记的可卡因类似物2β-甲氧羰基-3β-[4-碘苯基]托烷（β-CIT）通过正电子发射断层扫描（PET）研究多巴胺再摄取位点。
对3名正常受试者和9名帕金森病患者进行了研究。他们每人都用[11C]-β-CIT进行了动态PET扫描（80分钟内25个时间帧）。静脉注射102.5 - 211.3 MBq（2.77 - 5.71 mCi）的这种配体，并使用ECAT 931/08 PET相机进行PET检查。计算该放射性配体在纹状体/皮质/丘脑/中脑和小脑摄取之间的比率。
在尾状核和壳核中观察到[11C]β-CIT的最高积聚，尽管丘脑和中脑也有一些摄取。皮质摄取可忽略不计。帕金森病患者壳核中碳-11-β-CIT的积聚明显少于正常受试者。帕金森病患者壳核与小脑的比率为1.59±0.04，正常受试者为1.80±0.13（p = 0.028）。在尾状核中，帕金森病患者与正常受试者之间没有显著差异。
这些结果表明，[11C]β-CIT是一种用于对正常和病理大脑中突触前单胺能神经元功能进行PET检查的有用化合物。
