Chan V, Greenough A, Milner A D
Department of Child Health, King's College Hospital, London, U.K.
J Perinat Med. 1994;22(5):387-91. doi: 10.1515/jpme.1994.22.5.387.
The efficacy of a new ventilator, incorporating a valveless pneumatic exhalation circuit, at rates of up to 250 bpm was first assessed in the laboratory. Using this ventilator the effect of fast rate ventilation on blood gases of infants with acute respiratory distress was then examined. Infants were studied at three rates: 60, 125 and 250 bpm. Peak inflating and positive end expiratory pressure, inspiratory: expiratory ratio and inspired oxygen were kept constant. The laboratory study demonstrated that as ventilator rate was increased the delivered volume fell, but even at 250 bpm the delivered volume was 7 ml. In the clinical study, oxygenation at 250 bpm was not significantly different from that at 60 bpm, but significantly lower than at 125 pbm. Carbon dioxide levels were significantly lower at 250 bpm that at 60 bpm, but did not differ significantly from that at 125 bpm. We conclude increasing ventilator rate from 125 to 250 bpm is not advantageous for infants ventilated for acute respiratory distress.
一种新型呼吸机，带有无阀气动呼气回路，其在高达250次/分钟的频率下的效能首先在实验室中进行了评估。然后使用这种呼吸机研究了快速通气对急性呼吸窘迫婴儿血气的影响。以三种频率对婴儿进行研究：60次/分钟、125次/分钟和250次/分钟。峰值充气压力、呼气末正压、吸气:呼气比和吸入氧保持恒定。实验室研究表明，随着呼吸机频率增加，输送气量下降，但即使在250次/分钟时输送气量仍为7毫升。在临床研究中，250次/分钟时的氧合与60次/分钟时无显著差异，但显著低于125次/分钟时。250次/分钟时的二氧化碳水平显著低于60次/分钟时，但与125次/分钟时无显著差异。我们得出结论，对于因急性呼吸窘迫而接受通气的婴儿，将呼吸机频率从125次/分钟提高到250次/分钟并无益处。
