Greenough A, Pool J, Greenall F, Morley C, Gamsu H
Department of Child Health, King's College Hospital, London, United Kingdom.
Acta Paediatr Scand. 1987 Sep;76(5):706-12. doi: 10.1111/j.1651-2227.1987.tb10553.x.
The effectiveness of three different ventilator rates of artificial ventilation (30, 60 and 120/min) was studied in 32 preterm infants, all of whom were suffering from the Respiratory Distress Syndrome (16 were paralysed). Ventilator pressures, I:E ratio and MAP were kept constant at each rate. Increase in rate from 30 to 60 and to 120/min was well tolerated and not associated with episodes of hypotension. The only significant improvement in oxygenation was amongst the non-paralysed infants and at a rate of 120/min (p less than 0.01) this was associated with synchronous respiration. Two different ventilators were used in the study and a significant change in PaCO2 (reduction) occurred only in non-paralysed infants ventilated at a rate of 120/min by Sechrist ventilators (p less than 0.05). This difference may be a direct reflection of differences in ventilator performance at fast rates.
在32名早产婴儿中研究了三种不同人工通气频率（30、60和120次/分钟）的有效性，所有这些婴儿均患有呼吸窘迫综合征（其中16名已麻痹）。在每个频率下，通气压力、吸呼比和平均气道压均保持恒定。频率从30次/分钟增加到60次/分钟再到120次/分钟时耐受性良好，且与低血压发作无关。唯一显著的氧合改善发生在未麻痹的婴儿中，且在频率为120次/分钟时（p<0.01），这与同步呼吸有关。该研究使用了两种不同的呼吸机，仅在使用Sechrist呼吸机以120次/分钟的频率通气的未麻痹婴儿中，动脉血二氧化碳分压（PaCO2）出现了显著变化（降低）（p<0.05）。这种差异可能直接反映了快速通气时呼吸机性能的差异。
